PSMA I&S
GMP Grade
Precursor for radiometal-labelled PSMA I&S
Prostate-specific membrane antigen for SPECT imaging & radioguided surgery
Molecular Weight:
1299.4 (av.)
Molecular Formula:
C59H82N10O21S
PSMA I&S (GMP Grade)
General Information
Product name: PSMA I&S (TFA salt) / Mannitol
Synonyms: Mas3-y-naI-k(sub-KuE)
Sequence: Suber-1-oyl-ε-(Mercaptoacetyl-dSer-dSer-dSer-dTyr-d2Nal-dLys-OH)-8-oyl-ε-(HO-Glu-ureido-Lys-OH)
Molecular Weight: 1298.5 (m.i.), 1299.4 (av.)
Molecular Formula: C59H82N10O21S
Product description
Precursor for 99mTc-PSMA I&S [1-3].
For use by qualified personnel only.
Quantity
Product No. 50118: 40 µg net peptide (lyophilisate, (TFA) / 4mg mannitol)
Packaging
2 mL ISO clear type I tubular glass vials (2R borosilicate clear glass vials type I);
13mm crimp neck;
Lyophilisation stoppers;
Flip-off aluminium caps.
Storage and Stability
Store the product at temperatures – 20°C ± 5 °C and protected from light.
Toxicology/Hazards
Handle with care, avoid inhalation, ingestion, eye or skin contact, no toxicological data available.
Certificates
Certificate of Analysis
Certificate of Compliance
TSE/BSE Statement on request
Manufactured in full compliance with current GMP requirements. Specifications according to Ph. Eur. 2902 “Chemical precursors for radiopharmaceutical preparations”.
Literature
[1] Robu S. et al. Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer, J Nucl Med, 2017, 58, 235-242
[2] Maurer T. et al. 99mTechnetium-based PSMA-specific Membrane Antigen-radioguided Surgery in Recurrent Prostate Cancer. Eur Urol. 2018 Apr 3. pii: S0302-2838(18)30189-1
[3] Aalbersberg E. A. et al. Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow). EJNMMI Radiopharmacy and Chemistry, 2020 (5),10
