PSMA I&S

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PSMA I&S

PSMA I&S (TFA salt) / Mannitol

PSMA I&S (GMP Grade)

General Information

Product name: PSMA I&S (TFA salt) / Mannitol
Synonyms: Mas3-y-naI-k(sub-KuE)
Sequence: Suber-1-oyl-ε-(Mercaptoacetyl-dSer-dSer-dSer-dTyr-d2Nal-dLys-OH)-8-oyl-ε-(HO-Glu-ureido-Lys-OH)
Molecular Weight: 1298.5 (m.i.), 1299.4 (av.)
Molecular Formula:  C59H82N10O21S

Applications

Precursor for 99mTc-PSMA I&S [1,2,3].

Quantity and Packaging

40 µg net peptide PSMA I&S, 4 mg mannitol

in 2 mL ISO clear type I tubular glass vials,
13mm crimp neck sealed with lyophilisation stoppers,

flip-off aluminium caps

Storage and Stability

Store the product at temperatures – 20°C ± 5 °C and protected from light.

Toxicology/Hazards

Handle with care, avoid inhalation, ingestion, eye or skin contact, no toxicological data available.

Certificates

Certificate of Analysis

Certificate of Compliance

TSE/BSE Statement

Manufactured in full compliance with current GMP requirements. Specifications according to Pharm. Eur. 2902 “Chemical precursors for radiopharmaceutical preparations”.

Literature

[1] Robu S. et al. Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer, J Nucl Med, 2017, 58, 235-242

 [2] Maurer T. et al. 99mTechnetium-based PSMA-specific Membrane Antigen-radioguided Surgery in Recurrent Prostate Cancer. Eur Urol. 2018 Apr 3. pii: S0302-2838(18)30189-1

 [3] Aalbersberg E. A. et al. Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow). EJNMMI Radiopharmacy and Chemistry, 2020

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