GMP Production of

[F-18]siPSMA and [F-18]siTATE:


​• very fast production (<15min)


• at room temperature, thus without volatile 18F-activity


• high yields


• small and simple module


• small and simple cassette and reagent kit


• unparalleled cost efficiency


Radiochemical yield:

​50 % (*)

​Synthesis Time :

< 15 min

​Specific activity:

300 GBq/µmol (**)

applicable to:

​all SiFA tracers

** results from >400 clinical GMP production (starting activities from 30-100GBq)

   

*   using 100 GBq [18F]fluoride and 150 nmol precursor (typical value)



References:    

Wurzer A et al. J Nucl Med. 2019 (accepted) 


​​​siGRP Module


​​​For production of the ​[​F-18]siPSMA and [F-18]SiFAlin-TATE and new upcoming SiFA-Tracers we have designed a dedicated GRP Module that provide considerable advantages:

Production of [F-18]SiFA-based radiopharmaceuticals ​

​The labeling process:



​•​ SPE of [18F]F- on QMA


• on-cartridge drying of [F-18]fluoride
(patent protected)


•​ ​elution of QMA 


• labeling at room
temerature for 5 min


•​ ​dilution and SPE


• washing, elution,        filtration
and dilution


• automated on a

module especially designed for SiFA-labeling   

​​​The siGRP Module​



References:    

Wurzer A et al. ​ (manuscript in preparation)

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