PSMA I&T

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PSMA I&T

Precursor for radiometal-labelled PSMA I&T

PSMA: prostate-specific membrane antigen

I&T: Imaging & Therapy

PSMA I&T (GMP Grade)

General Information

Product name: PSMA I&T (TFA salt)
Synonyms: (R)-DOTAGA-(I-y)fk(Sub-KuE)
Sequence: Suber-1-oyl-ε-(DOTA-GA-3-iodo-D-Tyr-D-Phe-D-Lys-OH)-8-oyl-ε-(HO-Glu-ureido-Lys-OH)
Molecular Weight: 1497.5 (m.i.), 1498.4 (av.)
Molecular Formula: C63H92IN11O23

Applications

Enantiomeric pure labelling precursor for 177Lu-, 68Ga- and 225Ac-labeld PSMA I&T [1-4].

Quantity and Packaging

Product No. 50009 – 250 µg net peptide

Product No. 50107 – 1000 µg net peptide

2 mL ISO clear type I tubular glass vials with 13mm crimp neck; Lyophilisation stoppers, Flip-off seal

Storage and Stability

Storage at -20°C (± 5 °C). Protect from light.

Short-term storage up to 10 days at higher temperatures <+25°C (± 2°C) does not affect product quality.

Certificates

Certificate of Analysis

Certificate of Compliance

TSE/BSE Statement

Manufactured in full compliance with current GMP requirements. Specifications according to Pharm. Eur. 2902 “Chemical precursors for radiopharmaceutical preparations”.

Literature

[1] Weineisen M. et al. 68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies. J Nucl Med, 2015, 56(8):1169-76

[2] Fendler WP. Et al. 68Ga-PSMA PET/CT: Joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0.Eur J Nucl Med Mol Imaging, 2017, 44(6):1014-1024.

[3] Kulkarni HR wt a. PSMA-Based Radioligand Therapy for Metastatic Castration-Resistant Prostate Cancer: The Bad Berka Experience Since 2013. J Nucl Med. 2016, 57(Suppl 3):97S-104S.

[4] von Eyben FE. et al. Third-line treatment and 177Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review. Eur J Nucl Med Mol Imaging, 2018, 45(3):496-508.